Innate Immunity and Alcohol PMC
Following chronical excessive alcohol intake, the intestinal barrier becomes “leaky” by altered tight junctions of epithelial cells. On the one hand, alcohol impairs the trafficking of zona occludens (ZO)-1 and occludin, both proteins of tight junctions [209]. On the other hand, patients with alcoholic liver disease display increased intestinal levels of miR-212 that in turn …